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Microscopic neuronal changesinclude distinct contortions of neurofibrils termed neuro-fibrillary “tangles,” with structures outside of the neuronknown as neuritic plaques, composed of an amyloid coresurrounded by degenerating dendrites and axons. In effect,what the cross-linker did was destroy the ability of the CD80/86 molecules of the APC tomake contact with the T cell CD28 receptor

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Yaswen P, Campisi J (2007) Oncogene-induced senescence pathways weave an intricate tap-estry.
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